Confounding Risk Factors in Developing Type 1 Diabetes Mellitus among Children and Adolescents at Sulaimani Chronic Diabetes Health Center

Diabetic and risk factors

https://doi.org/10.24017/science.2021.1.7

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Authors

  • Pary Mohammad Azize Nursing Department-Sulaimani Technical Institute-Sulaimani Polytechnic University-Sulaimani- Iraq
  • Chia H. Sadiq Midwifery Department-Sulaimani Technical Institute-Sulaimani Polytechnic University-Sulaimani- Iraq

Abstract

Diabetes mellitus is one of the most common chronic health condition worldwide and the most common endocrine disease in children and adolescences. The aim of this study is to find out the risk factors, which lead to pathogenesis of type 1 diabetes mellitus among children and adolescent in diabetes health center Suleimani city. A descriptive cross sectional study was conducted at a special center for Type 1 Diabetes Miletus A questionnaire was developed and administered to a convenience sample of (170 ) mothers or fathers. Descriptive statistics data (frequency, percentage, mean and stander deviation) and also Factorial analysis (principal component analysis) was used in order to identify the effective factors affecting diabetes in children and Adolescents. The finding show that, 39.4 %  of samples were aged between (9-13) years old, which stated as the highest rate among all age groups, while the minority of age was between (1-4) years old, which was equal to 8.2% of the total and the (Mean ±S.D) was equal to 10.44±4.04 respectively. The majority of age at diagnosis was between (5-8) years old, which is 35.3% and their food habit was normal diet, which is 73.5%, while the Sugar diet and Fatty diet were 25.9% and 0.6%y respectively. Most of the participants, 19.4% of  family history was Type 2 diabetes, which was the first rank of the family history and majority of them were Kurdish in nationality. Age at diagnosis and mode of delivery considered as the first factor affect the type 1 diabetics mellitus. The second most common factor effect on diabetes disease in children and adolescents are maternal habit and maternal disease followed by Gestational age at birth and Neonatal disease, then food habits, Neonatal weight was estimated as the fourth component factors affecting Type 1 diabetes mellitus.  Residency and Family history of autoimmune disease were ranked in the fifth line of factor, finally the weakest factor is nationality by total variance of 8.552%. The first years of life is play an important role in triggering and the development of  type 1 diabetes mellitus among children and adolescent , also maternal diseases ( gestational diabetes, pre-eclampsia and perinatal infection during pregnancy), healthy diet during pregnancy and education programs are recommended

 

Keywords:

Effect, type 1diabetes mellitus, children, adolescence, chronic, diabetes centre

References

[1] E Hyppönen, SM Virtanen , MG Kenward , M Knip , HK Akerblom, ''Obesity, increased linear growth, and risk of type 1 diabetes in children''. Diabetes care journal. 23(12): 1755-60. 2000.
https://doi.org/10.2337/diacare.23.12.1755
[2] DM Maahs , JM West NA, Lawrence , EJ Mayer-Davis , "Epidemiology of type 1 diabetes". Endocrinology and Metabolism Clinics .39 (3): 481-97. 2010.
https://doi.org/10.1016/j.ecl.2010.05.011
[3] DW Cooke , L Plotnick , " Type 1 diabetes mellitus in pediatrics". pediatr Rev. 29 (11). 374-84, 2008 DOI: 10.1542/pir.29-11-374.
https://doi.org/10.1542/pir.29-11-374
[4] JW Yoon, "The role of viruses and environmental factors in the induction of diabetes". Current topics in microbiology and immunology, Rev. (1;164). 95-123, 1990. DOI: 10.1007/978-3-642-75741-9_6.
https://doi.org/10.1007/978-3-642-75741-9_6
[5] AA Majeed AA, KH Mea, ''Risk factors for type1 diabetes mellitus among children and adolescents in Basrah".Oman medical journal. 26(3): 189. 2011.
https://doi.org/10.5001/omj.2011.46
[6] MA Atkinson , GS Eisenbarth , "Type 1 diabetes: new perspectives on disease pathogenesis and treatment", The Lancet, 21;358 (9277). 221-229. 2001.
https://doi.org/10.1016/S0140-6736(01)05415-0
[7] American Diabetes Association, " 2. Classification and diagnosis of diabetes". Diabetes care,1(38), (Supplement 1) S8-16, 2015.
https://doi.org/10.2337/dc15-S005
[8] RA Insel , JL Dunne , MA Atkinson , JL Chiang , D Dabelea D, PA Gottlieb, CJ Greenbaum , KC Herold , JP Krischer , A Lernmark , RE Ratner , "Staging presymptomatic type 1 diabetes: a scientific statement of JDRF''. the Endocrine Society, and the American Diabetes Association. Diabetes care, 1;38(10): 1964-1974,.2015.
https://doi.org/10.2337/dc15-1419
[9] J Ilonen , A Hammais , AP Laine , J Lempainen , O Vaarala , RVeijola , O Simell , M Knip , " Patterns of ?-cell autoantibody appearance and genetic associations during the first years of life". Diabetes: 1;62(10): 3636-3640. 2013.
https://doi.org/10.2337/db13-0300
[10] M Rewers , J Ludvigsson , "Environmental risk factors for type 1 diabetes". The Lancet: 4;387(10035): 2340- 2348. 2016.
https://doi.org/10.1016/S0140-6736(16)30507-4
[11] RD Leslie , MD Castelli , " Age-dependent influences on the origins of autoimmune diabetes", evidence and implications, Diabetes, 1;53(12): 3033-3040, 2004.
https://doi.org/10.2337/diabetes.53.12.3033
[12]MA Moussa , M Alsaeid , TM Refai , N Abdella , N Al-Sheikh ,JE Gomez , '' Factors associated with type 1 diabetes in Kuwaiti children". Acta diabetologica, 1;42(3): 129-137.2005.
https://doi.org/10.1007/s00592-005-0192-0
[13] S. Saraswathi , S. Al-Khawaga ,N. Elkum, and K.Hussain, "A Systematic Review of Childhood Diabetes Research in the Middle East Region". Frontiers in Endocrinology. (10): 805. 2019.
https://doi.org/10.3389/fendo.2019.00805
[14] S. Šipeti?, , H. Vlajina , N. Koce , J. Marinkovi? , S. Radmanovi?, and L. Deni?, " Family history and risk of type 1 diabetes mellitus". Acta diabetologica. 39(3): 111-115. 2002.
https://doi.org/10.1007/s005920200028
[15] J Wahlberg , J Fredriksson , E Nikolic , O Vaarala , J. Ludvigsson " Environmental factors related to the induction of beta?cell autoantibodies in 1?yr?old healthy children", ABIS?Study Group, Pediatric diabetes. 6(4): 199-205. 2005.
https://doi.org/10.1111/j.1399-543X.2005.00129.x
[16] E. Altobelli , F. Chiarelli , M.Valenti, A.Verrotti, A. Blasetti, and F. Di Orio, "Family history and risk of insulindependent diabetes mellitus". A population-based case-control study, Acta diabetologica, 35(1): 57-60. 1998.
https://doi.org/10.1007/s005920050102
[17] L Levin , Y Ban , E Concepcion , TF Davies , DA Greenberg , Y Tomer , "Analysis of HLA genes in families with autoimmune diabetes and thyroiditis". Hum Immunol. 65(6): 640-647. 2004 , doi: 10.1016/j.humimm.2004.02.026. PMID: 15219384
https://doi.org/10.1016/j.humimm.2004.02.026
[18] N. Visalli, L. Sebastiani , E Adorisio , A. Conte, A.L. De Cicco , R. D'Elia, S. Manfrini, P. Pozzilli, "Environmental risk factors for type 1 diabetes in Rome and province, IMDIAB Group, Archives of disease in childhood. 88(8): 695- 698. 2003.
https://doi.org/10.1136/adc.88.8.695
[19] G.G. Dahlquist, S. Ivarsson , B. Lindberg, and M. Forsgren, " Maternal enteroviral infection during pregnancy as a risk factor for childhood". IDDM: a population-based case-control study, Diabetes. 44(4): 408-413, 1995.
https://doi.org/10.2337/diabetes.44.4.408
[20 ]L.C. Stene , P. Magnus, R.T. Lie, O. Søvik, O. and G. Joner , " No association between preeclampsia or cesarean section and incidence of type 1 diabetes among children". A large, population-based cohort study, Pediatric research. 54(4): 487-490. 2003.
https://doi.org/10.1203/01.PDR.0000081301.25600.5D
[22] M Ayati, AH Movahedian , Z. Mosayebi , "Assessment of Correlations Between Neonatal Jaundice and Phototherapy With Childhood Diabetes Type 1 ", Acta Med Iran. 58(30): 126-129. 2020.
https://doi.org/10.18502/acta.v58i3.3777
[22] R. Ievins , S.E. Roberts, and M.J., Goldacre , "Perinatal factors associated with subsequent diabetes mellitus in the child", record linkage study, Diabetic Medicine. 24(6): 664-670. 2007.
https://doi.org/10.1111/j.1464-5491.2007.02147.x
[23] C.R., Cardwell.,L.C., Stene, G.,Joner , E.A., Davis, O. Cinek, J. Rosenbauer, , J. Ludvigsson, C. Castell, J. Svensson , M.J Goldacre and T. Waldhoer," Birthweight and the risk of childhood-onset type 1 diabetes", a metaanalysis of observational studies using individual patient data, Diabetologia. 53(4): 641-651. 2010.
https://doi.org/10.1007/s00125-009-1648-5
[24] L.C., Stene , K.S., Rønningen , M. Bjørnvold, D.E. Undlien, and G. Joner," An inverse association between history of childhood eczema and subsequent risk of type 1 diabetes", that is not likely to be explained by HLA?DQ, PTPN22, or CTLA4 polymorphisms, Pediatric diabetes. 11(6): 386-393. 2010.
https://doi.org/10.1111/j.1399-5448.2009.00605.x
[25]G.G Dahlquist , C. Patterson, and G. Soltesz , "Perinatal risk factors for childhood type 1 diabetes in Europe". The EURODIAB Sub study 2 Study Group, Diabetes care. 22(10): 1698-1702. 1999.
https://doi.org/10.2337/diacare.22.10.1698
[26] CR Cardwell , LC Stene , G Joner , O Cinek, J Svensson , MJ Goldacre , RC Parslow , P Pozzilli , G Brigis , D Stoyanov , B Urbonaité , S Šipeti( E Schober , C Ionescu-Tirgoviste , G Devoti , CE de Beaufort , K Buschard , CC Patterson , " Caesarean section is associated with an increased risk of childhood onset type 1 diabetes mellitus". a metaanalysis of observational studies, Diabetologia . (51): 726-735. 2008.
https://doi.org/10.1007/s00125-008-0941-z

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How to Cite

[1]
P. M. Azize and C. H. Sadiq, “Confounding Risk Factors in Developing Type 1 Diabetes Mellitus among Children and Adolescents at Sulaimani Chronic Diabetes Health Center: Diabetic and risk factors”, KJAR, vol. 6, no. 1, pp. 56–68, Jul. 2021, doi: 10.24017/science.2021.1.7.

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Published

07-07-2021

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Pure and Applied Science