Chemotherapy-related side effects in childhood cancer in Hiwa Hospital Sulaimani city/Kurdistan region, Iraq
- chemotherapy, childhood cancer, side effects, routine clinical care, oncology, hematology
How to Cite
Cancer cells tend to grow fast, and chemo drugs kill fast-growing cells. However, since such drugs move to almost all part of the body, they might have an influence on healthy cells which are normal and grow fast. If healthy cells are damaged, there will be several side effects. The side effects of chemotherapy in children are reported by cancer treatment teams; however, only little evidence is available on the routine clinical care. The present study aimed to assess chemotherapeutic side effects in children with cancer. A single chemo drug can treat cancer; however, in order to come up with better and quicker results, sometimes a number of drugs are used in a specific order or combination which is referred to as combination chemotherapy. More cancer cells can be killed using different drugs which have different working mechanisms. As a result of this method, the cancer will have more limited chances to become resistant to an of the chemo drugs. The present descriptive study consisted of 300 children who underwent chemotherapy, and interviews were carried out with them. The severity of side effects was calculated according to three grades: low, moderate, and high. The collected data was collected through direct interview with the child greater than 6 years old on side effects of chemotherapy on physical health. Chemotherapy affects the entire cell inside the body among children. The results demonstrated that chemotherapy commonly affects the gastrointestinal tract and musculoskeletal system.
 R. W. Ruddon, Cancer biology, 4th ed. US: Oxford University Press, 2007.
 A. Turkcan, B. Zeng, and M. Lawley, "Chemotherapy operations planning and scheduling," IIE Transactions on Healthcare Systems Engineering, vol. 2, pp. 31-49, 2012.
 M. T. Dorak and E. Karpuzoglu, "Gender differences in cancer susceptibility: an inadequately addressed issue," Frontiers in genetics, vol. 3, p. 268, 2012.
 N. R. Council, Childhood cancer survivorship: improving care and quality of life: National Academies Press, 2003.
 D. A. Siegel, S. J. Henley, J. Li, L. A. Pollack, E. A. Van Dyne, and A. White, "Rates and trends of pediatric acute lymphoblastic leukemia-United States, 2001-2014," MMWR. Morbidity and mortality weekly report, vol. 66, p. 950, 2017.
 H. M. Parsons, L. C. Harlan, C. F. Lynch, A. S. Hamilton, X.-C. Wu, I. Kato, et al., "Impact of cancer on work and education among adolescent and young adult cancer survivors," Journal of Clinical Oncology, vol. 30, p. 2393, 2012.
 A. Tsimicalis, L. Genest, B. Stevens, W. J. Ungar, and R. Barr, "The impact of a childhood cancer diagnosis on the children and siblings' school attendance, performance, and activities: A qualitative descriptive study," Journal of Pediatric Oncology Nursing, vol. 35, pp. 118-131, 2018.
 C. H. Chui, M. Y. Chan, A. M. Tan, Y. Low, T. L. Yap, and A. S. Jacobsen, "Appendicitis in immunosuppressed children: Still a diagnostic and therapeutic dilemma?," Pediatric blood & cancer, vol. 50, pp. 1282-1283, 2008.
 F. M. Schnell, "Chemotherapy-induced nausea and vomiting: the importance of acute antiemetic control," The oncologist, vol. 8, pp. 187-198, 2003.
 C. Farrell, S. G. Brearley, M. Pilling, and A. Molassiotis, "The impact of chemotherapy-related nausea on patients' nutritional status, psychological distress and quality of life," Supportive Care in Cancer, vol. 21, pp. 59-66, 2013.
 C. W. Sullivan, H. Leutwyler, L. B. Dunn, B. A. Cooper, S. M. Paul, J. D. Levine, et al., "Stability of symptom clusters in patients with breast cancer receiving chemotherapy," Journal of pain and symptom management, vol. 55, pp. 39-55, 2018.
 R. L. Woodgate, L. F. Degner, and R. Yanofsky, "A different perspective to approaching cancer symptoms in children," Journal of Pain and Symptom Management, vol. 26, pp. 800-817, 2003.
 G. Pentheroudakis and N. Pavlidis, "Late toxicity in survivors from adolescent cancers," Cancer treatment reviews, vol. 33, pp. 656-663, 2007.