Isolation of Karanjin from Pongamia Pinnata and Its Identification by Difference Analytical Techniques
https://doi.org/10.24017/science.2018.2.26
Abstract views: 1565 / PDF downloads: 916Abstract
Karanjin is the medicinal drug that used as anti- inflammatory and anti-cancer. The object of this study is to isolate karanjin in karanja (pongamia pinnata Linn.) seed oil. The seed oil was subjected to triple petroleum with continuously constant shaking for first 48 hours, 24 hours for each second and third extraction then separated under reduced pressure at 50?C on rotatory evaporate to get yellow viscous oil. Separate non-fatty components using ethanol solvent and reduced under 50?C with pressure to get (43.33 g) yellow oil. The oil was kept for 3 days at 45?C in refrigerator white deposited at bottom of oil, the residue recrystallized with methanol it should be done fast and carefully to prevent solubility of karanjin in methanol partially, the purity of isolated karanjin was found to be (99.623%). From TLC, HPL, IR, 1HNMR, 13CNMR spectra data, structure elucidation was done and the structure was confirmed as karanjin.
Keywords:
Karanjin, pongamia pinnata, Karanja oil, medicinal plant.
References
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https://doi.org/10.1016/0031-9422(80)83083-4
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https://doi.org/10.1016/j.phytochem.2006.05.016
[26] K. R. Kritikar, B. D. Basu, "Indian Medicinal Plants," 2nd edn. International Book Distributions, Dehradune, India, 1995.
[27] L. D. Kapur, "Traditional uses of medicinal plants," Ayurvedic Medicinal plants 327, 2001.
[28] R. K. Singh, V. K. Joshi, R. K. Goel, S. S. Gambhir, S. B. Acharya, "Pharmacolog¬ical action of P. pinnata seed -A preliminary study," Ind J ExpBiol 34:1204-1207. 1996.
[29] R. Punitha, K. Vasudevan, S. Manoharan, "Effect of Pongamia pinnata flow¬ers on blood glucose and oxidative stress in alloxan induced diabetic rats," Ind J Pharmacol38: 62-63, 2006.
https://doi.org/10.4103/0253-7613.19858
[30] T. Prabha, M. Dora Babu, S. Priyambada, V. K. Agrawal, R. K. Goel, "Evaluation of Pongamia pinnata root extract on gastric ulcers and mucosal offensive and defensive factors in rats," Ind J ExpBiol41: 304-310, 2003.
https://doi.org/10.1007/978-1-349-06142-6
[2] V. V. Chopade, A. N. Tankar, V. V. Pande, A. R. Tekade, N. M. Gowekar, S. R. Bhadari, S. N. Khandake, "International J. of Green Pharmacy," April- June, 2008.
[3] S. A. Dahanukar, R. A. Kulkarni, N. N. Rege, "Pharmacology of medicinal plants and natural products," Indian Journal of Pharmacology; 32: S81-S118, 2000.
[4] C. Orwa, A, Mutua, R. Kindt, R. Jamnagass, S. Anthony, "Agroforest tree Database,"; 491p, 2009.
[5] B. Meera, S. B. Kalidhar, "Chemical components of Pongamia pinnata L," J Ind Chem Soc; 81: 891-892, 2004.
[6] M. Bimla, S. Kumar, S. B. Kalidhar, "A review of chemistry and biological activity of P. pinnata'" J Med Arom Plant Sci 25: 441-465.
[7] P. Lakshmni, G. Srimannaragana, S. N. V. Rao, "Pongaflavone, a new chromenochromone and an analog of karanjin isolated from Pongamia pinnata," Indian J Chem; 12: 8-9, 1974.
[8] R. N. Khanna, T. R. Seshadri. "Pongaglabrone, a new component of the seeds of Pongamia glabra, its constitution and synthesis," Tetrahedron; 19: 219-225, 1963.
https://doi.org/10.1016/0040-4020(63)80024-1
[9] K. Simin Shameel, M. UsmanGhani, S. Ali and V. U. Amad, "Chemical constituents from the Seed of Pongamia Pinnata (L.) Pirre," Pakistan Journal of Pharmaceutical SCIENCES January, 9 ,: 11-20, 1996.
[10] S. Koysomboon, I. Van Altena, S. Kato, K. Chantrapromma, "Antimycobacte¬rial flavonoids from Derris indica,". Phytochemistry 67: 1034-1040, 2006.
https://doi.org/10.1016/j.phytochem.2006.03.019
[11] H. G. Champion, S. K. Seth, "Revised Survey of Forest Types of India," Manager of Publication, GOl, New Delhi, 1968.
[12] B. J. Vinay, T. C. Sindhu Kanya, "Effect of detoxification on functional and nutritional quality of proteins of karanja seed meal,". Food Chem. 106, 77-84, 2008.
https://doi.org/10.1016/j.foodchem.2007.05.048
[13] T. Prabha. M. Dorababu, G. Shalini, P. K. Agarwal, V. K. Joshi, R. K. Goel, "effect of methanolic extract of p. pinniata linn seed on gastro duodenal ulceration and mucosal offensive factors in rats," Indian Journal of Experimental Biology August, 47, 649-659, 2009.
[14] M. M. Essa, S. Perumal, S. Ganapathy, M. Tamilarasan, B. D. Kadiyala, "protective influence of p. pinnata on blood ammonia and urea levels in ammonium chloride induced hyperammonemia,", J. Appl. Biomed,3: 1-5, 2005.
https://doi.org/10.32725/jab.2005.017
[15] M. Raghavendra, A. Trigunayat, R. K. Singh, S. Mitra, R. K. Goel, R, K. Acharrya, "effect of ethanolic extrac of root of pongamia pinnata Pongamia pinnata on stress, behavioral and histopathological alterations induce by cerebral ischemia," AlI Indian Journal of Experimental Biology , October, 45: 868-876, 2007.
[16] P. P. Joy, J. Thomas, S. Mathew, P. Skaria, "Aromatic and Medicinal Plants Research Station Odakkali, Asamannoor P.O., Ernakulam District, Kerala, India,"
[17] U. D. din Q, N. Parveen, N. U. Khan, K. C. Singhal, "Antifilarial potential of the fruits and leaves extracts of Pongamiapinnata on cattle filarial parasite," Setari¬acervi. PhytotherRes 17: 1104-1107, 2003.
https://doi.org/10.1002/ptr.1269
[18] M. Elanchezhiyan, S. Rajarajan, P. Rajendran, S. P. Thyagarajan, "Antiviral properties of the seed extract of an Indian medicinal plant P. Pinnata against herpes simplex viruses in vitro studied on vero cells," J Med. Microbiol,38: 262-264, 1993.
https://doi.org/10.1099/00222615-38-4-262
[19] S. Lakshmni, "The Wealth of India A Ready Reckoner on Biodiversity and Bioresources of India," NISCAIR, CSIR, New Delhi, India, 2003.
[20] C. P. Khare, "Indian Medicinal Plants, an illustrated dictionary," Springer-verlag Berlin/Heidelberg, New York, USA, 2004.
[21] R. P. Rastogi, B. N. Mehrotra, "Compendium of Indian medicinal plant," Cen¬tral Drug Research Institute and Publication and information Directorate, New Delhi, India, 1993.
[22] G. Ahmad, P. P. Yadav, R. Maurya "Furanoflavonoid glycosides from Pon¬gamiapinnata fruits," Phytochemistry 65: 921-924 ,2004.
https://doi.org/10.1016/j.phytochem.2004.01.020
[23] S. K. Talapatra, A. K. Mallik, B. Talapatra, "Pongaglabol, a new hydroxyfura¬noflavone, and aurantiamide acetate, a dipeptide from the flowers of Pongam¬iaglabra," Phytochemistry 19: 1199-1202, 1980.
https://doi.org/10.1016/0031-9422(80)83083-4
[24] R. P. Rastogi, B. N. Mehrotra, S. Sinha, P. Pant, R. Seth R, "Compendium of Indian medicinal plants," Central Drug Research Institute and Publications & Information Directorate, New Delhi, India, 2011.
[25] L. Li , X. Li, C. Shi, Z. Deng, H. Fu, "Pongamone A-E, five flavonoids from the stems of a mangrove plant, Pongamiapinnata," Phtochemistry 67: 1347- 1352, 2006.
https://doi.org/10.1016/j.phytochem.2006.05.016
[26] K. R. Kritikar, B. D. Basu, "Indian Medicinal Plants," 2nd edn. International Book Distributions, Dehradune, India, 1995.
[27] L. D. Kapur, "Traditional uses of medicinal plants," Ayurvedic Medicinal plants 327, 2001.
[28] R. K. Singh, V. K. Joshi, R. K. Goel, S. S. Gambhir, S. B. Acharya, "Pharmacolog¬ical action of P. pinnata seed -A preliminary study," Ind J ExpBiol 34:1204-1207. 1996.
[29] R. Punitha, K. Vasudevan, S. Manoharan, "Effect of Pongamia pinnata flow¬ers on blood glucose and oxidative stress in alloxan induced diabetic rats," Ind J Pharmacol38: 62-63, 2006.
https://doi.org/10.4103/0253-7613.19858
[30] T. Prabha, M. Dora Babu, S. Priyambada, V. K. Agrawal, R. K. Goel, "Evaluation of Pongamia pinnata root extract on gastric ulcers and mucosal offensive and defensive factors in rats," Ind J ExpBiol41: 304-310, 2003.
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How to Cite
[1]
S. Kumar Dhanmane and F. A. Salih, “Isolation of Karanjin from Pongamia Pinnata and Its Identification by Difference Analytical Techniques”, KJAR, vol. 3, no. 2, pp. 156–160, Jul. 2018, doi: 10.24017/science.2018.2.26.
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Published
23-07-2018
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Pure and Applied Science
