Effects of Celery Seed Extracts on Some Haematological and Biochemical Parameters in Albino Rats Treated with Gentamicin

Abstract = 454 times | PDF = 133 times

Main Article Content

Tavga Ismael Mustafa Zhakaw Khudir Abdullah Nazar Mohammed Shareef Mahmood Shorish Mustafa Abdullah Gorony Kurdo Bapir Chato Ranjbar Muksy Mohammed Shareef

Abstract

The present study targeted the influence of orally celery seeds (Apium graveolens) aqueous extract and ethanolic extracts on male albino rats injected with gentamicin intraperitoneally to investigate some hematological and biochemical parameters. Thirty-two male rats were weighing 300-400 gm carried out for the present research, they controlled environmentally. Animals were divided equally and randomly into four groups each of which contained eight rats. First group (control) included normal rats, group2 were given 100 mg/kg B.W. gentamicin (GM) intraperitoneally (IP), group3 (combined group) were given 100 mg/kg B.W. GM and 150 mg/kg B.W. celery seed ethanolic extract orally by needle gavage, and group4 (combined group) were given 100 mg/kg B.W. GM (IP) and celery seeds aqueous extract 150 mg/kg B.W. orally by needle gavage respectively the present study contiued for eight executive days. The results showed that the elevated by GM haematological parameters  lowered by the celery seed aqueous extract as compared to the celery seed ethanolic extract group, while the elevated serum malondialdehyde (MDA) and total cholesterol (TC) are decreased in group3 more than they were in the group4,  in contrast to that the triglyceride (TG), high density lipoprotein (HDL), low-density lipoprotein (LDL), serum creatinine (CR), serum uric acid (UA), and alkaline phosphatase (ALP) lowered in the group4 from the group 3. The present study concluded that both extracts of celery seeds play a vital biological role, including the improvement effects against the side effect of GM and offering health benefits through decreasing of elevated parameters.

Keywords

celery seed, gentamicin, ethanolic extract, aqueous extract.

Downloads

Download data is not yet available.

Article Details

References

[1] O. S. Khuon, "Role of Aqueous Extract of Apium graveolens Seeds Against the Haematotoxicity Induced by Carbon Tetrachloride," Journal of College of Education for Pure Science, vol. 2, no. 1, pp. 10-23, 2012.
[2] K. Mansi, A. M. Abushoffa, A. Disi, and T. Aburjai, "Hypolipidemic effects of seed extract of celery (Apium graveolens) in rats," Pharmacognosy magazine, vol. 5, no. 20, p. 301, 2009.
[3] N. M. A. El-Mageed, "Hepatoprotective effect of feeding celery leaves mixed with chicory leaves and barley grains to hypercholesterolemic rats," Pharmacognosy magazine, vol. 7, no. 26, p. 151, 2011.
[4] S. Alarifi et al., "Blood chemical changes and renal histological alterations induced by gentamicin in rats," Saudi journal of biological sciences, vol. 19, no. 1, pp. 103-110, 2012.
[5] A. Ateşşahin, I. Karahan, S. Yilmaz, A. Çeribaşi, and I. Princci, "The effect of manganese chloride on gentamicin-induced nephrotoxicity in rats," Pharmacological research, vol. 48, no. 6, pp. 637-642, 2003.
[6] R. Cronin and W. Henrich, "Toxic nephropathy," The kidney, vol. 2, pp. 1680-1711, 1996.
[7] A. Abdel-Gayoum, B. Ali, K. Ghawarsha, and A. Bashir, "Plasma lipid profile in rats with gentamicin-induced nephrotoxicity," Human & experimental toxicology, vol. 12, no. 5, pp. 371-375, 1993.
[8] H. Ahmadvand et al., "Effects of oleuropein on lipid peroxidation, lipid profile, atherogenic indices, and paraoxonase 1 status in gentamicin-induced nephrotoxicity in rats," ARYA Atherosclerosis, vol. 11, no. 2, p. 153, 2015.
[9] R. Manikandan, M. Beulaja, R. Thiagarajan, A. Priyadarsini, R. Saravanan, and M. Arumugam, "Ameliorative effects of curcumin against renal injuries mediated by inducible nitric oxide synthase and nuclear factor kappa B during gentamicin-induced toxicity in Wistar rats," European journal of pharmacology, vol. 670, no. 2-3, pp. 578-585, 2011.
[10] A. A. Banday, N. Farooq, S. Priyamvada, A. N. Yusufi, and F. Khan, "Time dependent effects of gentamicin on the enzymes of carbohydrate metabolism, brush border membrane and oxidative stress in rat kidney tissues," Life sciences, vol. 82, no. 9-10, pp. 450-459, 2008.
[11] R. K. Muslih, M. S. Al-Nimer, and O. AL-ZAMELY, "The level of malondialdehyde after activation with (H2O2) and (CuSO4) and inhibition by desferoxamine and molsidomine in the serum of patients with acute myocardial infarction," National journal of chemistry, vol. 5, pp. 139-148, 2002.
[12] S. El Badwi, A. Bakhiet, and E. Abdel Gadir, "Haemato-biochemical Effects of aqueous extract of Khaya senegalensis stem bark on Gentamicin-Induced Nephrotoxicity in Wistar Rats," J. Biol. Sci, vol. 12, pp. 361-366, 2012.
[13] A. E. R. A. Ashour, M. M. Yassin, N. M. A. AASI, and R. M. Ali, "Blood, serum glucose and renal parameters in lead-loaded albino rats and treatment with some chelating agents and natural oils," Turkish journal of Biology, vol. 31, no. 1, pp. 25-34, 2007.
[14] R. Abdelrahman, "Protective effect of apocynin against gentamicin-induced nephrotoxicity in rats," Human & experimental toxicology, vol. 37, no. 1, pp. 27-37, 2018.
[15] U. Rashid and M. R. Khan, "Fagonia olivieri prevented hepatorenal injuries induced with gentamicin in rat," Biomedicine & Pharmacotherapy, vol. 88, pp. 469-479, 2017.
[16] M. A. Algridi and A. E. Azab, "Amelioration of Gentamicin Induced Dyslipidemia in Guinea Pigs by Curcumin and Rosemary," Scientific Review, vol. 3, no. 2, pp. 6-16, 2017.
[17] B. Ali, A. A. Gayoum, and A. Bashir, "Gentamicin nephrotoxicity in rat: some biochemical correlates," Pharmacology & toxicology, vol. 70, no. 6, pp. 419-423, 1992.
[18] G. Tong, Y. Zhang, Y. Zhang, H. Li, and J. Liu, "Effect of celery seed extract on hyperuricemia in rats," Food Sci, vol. 12, p. 152, 2008.